A patient with focal segmental glomer ulosclerosis and renal insufficiency on case taking was found to have mild oedema and extreme irritability, and to drink 15 to 20 cups of tea or coffee per day. He was prescribed Nux vomica over a period of 8 to 10 months in increasing potency. Previous to homeopathic treatment the blood urea and serum creatinine were above normal and gradually increasing, whereas after 4 months of homeopathic treatment they showed a decrease and after another 5 months came down to normal. His other symptoms have all improved. The author infers from this case that prescribing a homeopathic drug on a constitutional basis stimulates the entire organism via a neuro-endocrine and immune system thus bringing changes at mental and physical levels.