This paper reveals the concepts of dissimilar disease. A case of renal and cardiac failure has been discussed. The patient having a number of serious conditions including intermittent renal and cardiac failure, recurrent pneumonia, recurrent pyelonephritis, hypertension, recurrent barking cough and history of ecampsia was treated with homoeopathy. She was given opium CM; Carb Veg CM; Glonoinum 50M; Crotalus Horridus 50 M; Naja CM; Digitalis CM; Kali Bich CM and Phosphorus on the basis of change of symptoms. The author expressed his views.