Title: Role of Free Energy & Entropy
Relationship between a System & its Surrounding for Determining the
Mechanism of Action of Higher Potencies of Pterocarpus
Marsupium - As Novel Anti- Arteriosclerotic Activity
Objective: To study the mechanism of action of higher potencies of
P. marsupium as a novel anti- arteriosclerotic activity.
Materials
& Methods: Different potencies
of P. marsupium Viz. 1x, 6x, 30x, 200x of succussed and unsuccused dilutions
were examined for its anti-arteriosclerotic activities in the experimentally
induced hyercholesterolemic rabbit. Cholesterol levels (Lieberman-Burchard
Reaction), triglyceride (Van-Hand and Zilversmite,1959) and Phospholipids
(Fiske et.al.1925) were found in the range of 45± 5mg % were selected for
inducing hypercholesterolemia in rabbits. Saline vehicle and test drugs fed
once a day for 45 days regularly. Blood samples were collected at in interval
of 15 days, 30 days and 45 days to examine biochemical & haematological
parameters, histopathological studies of arteries, brain, and vessels were also
undertaken from pretreated hypercholesterolemic animals and post-treated test
drug, saline & vehicle treated animals for interpretation of results.
Results: Experimental data revealed that the drug at a dose level
ranging from 50µ to 0.25ml /kg.b.w. in succussed dilutions exhibited highly
significant anti- arterisclerotic/ hypocholesterolemic activity i.e.
perceptible decrease in serum cholesterol levels, when compared to control, normal control and unsuccessed dilutions of
P. marsupium group under identical laboratory conditions.
Conclusion: The Pterocarpus marsupium in succeeded dilutions
possesses novel anti-arteriosclerotic potentiality and its duration of action
increases with potency since its Therapeutic action mediated through central
neuro-transmitters at a dose level ranging from 50µl to 0.25 µl/kg in
experimentally induced hypercholesterolemic rabbits. . Present probe also
confirms the concept of minimum dose, which implies that medicinal power of a
drug increases with its duration.
Published in: Drug Research, Homoeopathic Drug Research Institute, Annual Report 1990-91, 7-14.