CLINICAL VERIFICATION
 
INTRODUCTION
 
Homoeopathic Materia Medica is build upon signs and symptoms produced during proving of a drug on healthy human beings, toxic effects as observed during accidental poisoning or prolonged use of the drug and clinical symptoms (observed to disappear while drug is administered to sick person). The symptomatic data needs to be clinically verified on sick persons before it is included in the homoeopathic Materia Medica, which forms the basis of clinical prescription of the respective drug(s) on sick.

The Council had undertaken Clinical Verification of symptomatic data of 52 drugs, including those proved by the Council and those, which have had fragmentary proving and studies on these medicines have already been completed. In the year of 2005 Council decided to undertake Clinical Verification of the pathogenesis of those drugs only, which have been proved by the Council and thirty four (34) such drugs were undertaken in the study and subsequently the study on these medicines have been completed in March 2010 . Consequently, another 23 drugs proved by the Council have been compiled and has been undertaken for clinical verification in the present study. Most of the medicines taken up for verification are of Indian origin. Provings of these medicines indicate that many of these have vast potential for therapeutic use and thus their verification will add help to the profession. These findings assume significance in view of the Government’s policy on medicinal plants, which lays emphasis on promoting these drugs.

Primary Objective
 
To clinically verify the symptomatology of the following 23 drugs
1. Agave americana 12. Hydrocotyle asiatica
2. Andrographis paniculata 13. Juglans regia
3. Argemone mexicana 14. Liatris spicata
4. Bacopa monniere 15. Mimosa humilis
5. Chelone glabra 16. Ocimum sanctum
6. Clerodendron infortunatum 17. Paraffin
7. Coleus aromaticus 18. Pothos foetidus
8. Cornus circinata 19. Senega
9. Cup. oxydatum nigrum 20. Skookum chuck
10. Ficus religiosa 21. Thymol
11. Formic acid 22. Thyroidinum
23. Tinospora cordifolia
 
Secondary Objectives
To ascertain clinical symptoms (which were not observed during the proving but have disappeared in the sick during the study either partially or completely and are not mentioned in the referred literature).
 
Location of the study
The following Institutes/ Units are carrying out the research study keeping in view the adequacy of the research personnel and facilities of Laboratory investigations and willingness of the research personnel:
 
1 Central Research Institute, Noida
2 Homoeopathic Drug Research Institute, Lucknow
3 Regional Research Institute, Shimla
4 Regional Research Institute, Puri
5 Regional Research Institute, Gudiwada
6 Regional Research Institute, Imphal
7 Drug Proving Research Unit, Kolkata
8 Clinical Research Unit, Portblair
9 Clinical Verification Unit, Patna
     
  Study completed for the following drugs under clinical verification programme  
     
 
1 Aborma augusta
2 Acalypha indica
3 Achyranthes aspera
4 Acid butyricum
5 Aegle folia
6 Aegle marmelos
7 Alfaalfa
8 Alstonia constricta
9 Amoora rohituka
10 Amygdalus persica
11 Anthrakokali
12 Aranea diadema
13 Aranea scinencia
14 Arsenicum bromatum
15 Ars. sulph. flavum
16 Atista indica
17 Azadirachta indica
18 Bacillinum
19 Barytaiodata
20 Baryta muriaticum
21 Bellis perennis
22 Benzinum nitricum
23 Benzoicum acid
24 Berberis vulgaris
25 Blatta orientalis
26 Boerrhavia diffusa
27 Caesalpinia bonducella
28 Calotropis gigantea
29 Cannabis indica
30 Cannabis sativa
31 Carica papaya
32 Cassia fistula
33 Cassia sophera
34 Cephalandra indica
35 Chromo. kali sulph
36 Cuprum aceticum
37 Curcum longa
38 Cynodon dactylon
39 Damiana
40 Embelia ribes
41 Ephedra vulgaris
42 Euphorbia lathyris
43 Fagopyrum esculentum
44 Ferrum picricum
45 allicum acidum
46 Glycyrrhiza glabra
47 Gymnema sylvestre
48 Hecla lava
49 Holarrhena antidysenterica
50 Hydrocotyle asiatica
51 Hygrophilla spinosa
52 Ichthyolum
53 Iris tenax
54 Jaborandi
55 Jacaranda caroba
56 Jalapa
57 Juglans regia
58 Justicia adhatoda
59 Kali muriaticum
60 Lac caninum
61 Lapis albus
62 Magnesia sulphurica
63 Mangifera indica
64 Mentha piperata
65 Mygale lasiodora
66 Nyctanthes arbortristis
67 Ocimum canum
68 Oxytropis lamberti
69 Pyrus americana
70 Rauwolfia serpentine
71 Ricinus communis
72 Saraca indica
73 Sarsaparilla
74 Staphylococcinum
75 Syzygium jambolanum
76 Tarentula cubensis
77 Tarentula hispanica
78 Tela aranea
79 Terminalia arjuna
80 Terminalia chebula
81 Thea chinensis
82 Theridion
83 Tribulus terrestris
84 Tylophora indica
85 Viscum album
 
 
Out of these 85 medicines, 12 medicines have been published in the form of monographs and Clinically verified data of 24 medicines have been published in Council's Quarterly Bulletins and IJRH. A few abstracts of some of the published articles
are given below.
 
ALSTONIA CONSTRICTA
Abstract
Alstonia constricta has been used in Homoeopathy for many conditions like debility, diarrhea, dysentery, fevers, excessive lactation, leucorrhoea, palpitation, debility of uterus, as reported in various literatures. Most of these symptoms have been reconfirmed during the study and beside these loose stool with vomiting, chronic diarrhea, intermittent fever with profuse sweating, intermittent fever with diarrhea, dry cough etc. were also relieved by the medicine additionally while treating some other conditions and thus unfolding the hidden character of the medicine in various illnesses.

A total of 3854 patients participated in this multicentre study at various Units/Institutes under Central Council for Research in Homoeopathy to verify symptoms of Alstonia constricta, as mentioned in the homoeopathic Materia Medica.
 
BLATTA ORIENTALIS
Abstract
Blatta orientalis is a common cockroach in India and is found in Homoeopathic literature to relieve complaints of the patients suffering from asthma. It is also reported to be suited to the corpulent people and also useful in bronchitis where there is much dyspnoea. A total number of 6184 patients participated in this multicentric clinical study at various Institutes / Units under Central Council for Research in Homoeopathy to confirm the use of Blatta orientalis as mentioned in Homoeopathic Materia Medica with the objective of evolving its clinical drug picture. The study not only confirms its therapeutic use in cough, dyspnoea, asthmatic conditions, etc. as mentioned in various Homoeopathic literatures but also has delineated characteristics which would be helping in differentiating Blatta orientalis from other similar remedies given in Homoeopathic Materia Medica. Beside, a set of new symptoms were also observed to emerge as clinical symptoms during the study which indicates that, had the proving of this medicine be extensive enough, these symptom would have been generated.
 
FERRUM PICRICUM
Abstract
Homoeopathic literature for diseases/complaints like anaemia, malaria fever, impaired hearing, vertigo, epistaxis, tinnitus, loss of voice, indigestion, headache, tired feeling, sexual excesses, loss of blood, constipation, prostate enlargement, warts and corns. An open multicentric clinical study at various Institutes / Units under Central Council for Research in Homoeopathy was conducted to confirm the use of Ferrum picricum as mentioned in Homoeopathic Materia Medica and to add to its drug picture. For this 3,465 patients were enrolled in the study. The study not only confirms the therapeutic use of the drug in headache, vertigo, epistaxis, tinnitus aurium, loss of voice, constipation, enlargement of prostate, cough, corns, warts and debility, as mentioned in the Homoeopathic literature, but also delineates the characteristics which could help in differentiating Ferrum picricum from other similar remedies. Beside, a set of new symptoms also emerged as clinical symptoms increasing the scope of use of this medicine in clinical practice and suggest a comprehensive proving to get full picture of the drug.
 
FAGOPYRUM ESCULENTUM
Abstract
Fagopyrum esculentum has been used in Homoeopathy for many conditions like diarrhea, eczema, various eyes affections, headache, itching eruptions, pruritus pudenda, sore throat, tonsillitis, uvulitis, nausea, coryza and leucorrhoea. Most of these symptoms have been reconfirmed during the study and beside these styes, conjunctivitis, nasal obstruction, burning in rectum, pain in joints, boils and productive cough were also relieved by this medicine additionally while treating some other conditions and thus unfolding the hidden character of the medicine in various clinical conditions during the study. A total of 6675 patients participated in this multicentre study at various Units/Institutes under Central Council for Research in Homoeopathy to confirm the symptom of Fagopyrum esculentum, as mentioned in the Homoeopathic Materia Medica.
 
EPHEDRA VULGARIS
Abstract
Ephedra vulgaris is a lesser known drug which has been used in Homoeopathy for clinical conditions like exophthalmos (Grave's disease) and headache which was subjected to clinical verification during the study. Besides verification of its use in conditions like inflammation of thyroid gland, enlargement of thyroid gland, palpitation, stiffness of neck, disturbed sleep and general weakness, other clinical conditions in which it has been found useful are conjunctivitis, coryza, anorexia and warts. A total of 1657 patients were studied in this multicentric clinical verification trial at various Institutes/ Units under Central Council for Research in Homoeopathy to confirm the symptoms of Ephedra vulgaris, as mentioned in the Homoeopathic Materia Medica.
 
TARENTULA HISPANICA
Abstract
Tarentula hispanica is a known drug in Homoeopathy but it has not been used extensively. Its use has been reported in Homoeopathic literature for various clinical conditions like depression, headache, hiccough, quinsy, cystitis, vertigo, otorrhoea, pyrosis, constipation, seminal emission, neuralgia of legs, cough, dyspnoea and fever. Most of these symptoms have been reconfirmed in the study conducted by Central Council for Research in Homoeopathy (CCRH). Besides these, in conditions like conjunctivitis, dyspepsia, flatulence, loose stool, pain in deltoid region, pain in shoulder joints and in pimple like eruptions it is also found useful. A total of 2794 patients were studied in this multicentric clinical verification trial under CCRH to confirm the symptoms of Tarentula hispanica, as mentioned in the homoeopathic materia medica.
 
DAMIANA
Abstract
Damiana or Turnera aphrodisiaca has been traditionally used as an invigorating and aphrodisiac herb in different schools of medicine for centuries. In Homoeopathy, however,its use has been made besides the above conditions, for various other disorders like amenorrhoea, dysmenorrhoea, leucorrhoea, sterility and frigidity in females and spermatorrhoea, urinary tract infection in male it has been found to be a very useful medicine in treating migraine and also been used for incontinence of urine and affection of prostate in old people with success. The Central Council for Research in Homoeopathy undertook a clinical study to verify and confirm the uses of Damiana as mentioned in the homoeopathic materia medica with the objective of evolving its clinical drug picture. Three thousand thirty two patients, comprising of 2,383 males and 649 females were enrolled in the study. This study not only confirms its therapeutic use in sexual debility, impotency but also in migraine, leucorrhoea, dysmenorrhoea, constipation, affection of the prostate, general fatigue etc. as noted in the literature. It also has delineated characteristics, which would help in differentiating Damiana from other similar remedies given in the homoeopathic materia medica. Few new symptoms and signs were also noted during its clinical use as above, which may be confirmed in the proving of this drug in future.
 
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